Authors: Stulberg DB1, Rowland K.
Abstract: In "Colicky baby? Here's a surprising remedy" (J Fam Pract. 2011;60:34-36), we summarized a 2010 double-blind randomized controlled trial (RCT) that found the probiotic Lactobacillus reuteri DSM 17938 reduced daily crying time in colicky, exclusively breastfed infants. A recently published RCT of the same probiotic by Sung et al adds to the body of evidence and suggests that the jury may still be out as to the value of probiotics for colicky babies....
Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes.
Authors: Hood K1, Nuttall J1, Gillespie D1, Shepherd V1, Wood F2, Duncan D3, Stanton H1, Espinasse A1, Wootton M4, Acharjya A5, Allen S6, Bayer A2, Carter B2, Cohen D7, Francis N2, Howe R4, Mantzourani E8, Thomas-Jones E1, Toghill A9, Butler CC2.
Abstract: BACKGROUND: Antibiotic prescribing rates in care homes are higher than in the general population. Antibiotics disrupt the normal gut flora, sometimes causing antibiotic-associated diarrhoea (AAD). Clostridium difficile (Hall and O'Toole 1935) Prévot 1938 is the most commonly identified cause of AAD. Little is known either about the frequency or type of antibiotics prescribed in care homes or about the incidence and aetiology of AAD in this setting.OBJECTIVES: The Probiotics for Antibiotic-Associated Diarrhoea...
Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines.
Authors: Amdekar S1, Singh V1, Kumar A2, Sharma P3, Singh R4.
Abstract: Arthritis is an inflammatory disease of joints. Exact etiology of the disease is not understood yet; but histopathological examination of vital organs like liver, kidney, ovary and knee joint can anticipate immune mediated damage. In this study, Lactobacillus acidophilus was administered orally by both prophylactic and curative protocol in freund's complete adjuvant induced arthritic rats. Indomethacin was used as standard anti-arthritic drug. Histopathology of liver, kidney, ovary and right hind knee joint...
Authors: Mistry P.
Abstract: It is important to maintain healthy blood lipid profiles in order to reduce risk of cardiovascular disease. This article explores some of the evidence for natural cholesterol lowering products as a possible alternative to cholesterol lowering medication. Probiotics have been investigated for their effect on cholesterol levels and there is increasing evidence to support their use as a natural cholesterol lowering alternative....
Authors: Whelan K.
Abstract: Irritable bowel syndrome (IBS) and chronic idiopathic constipation are prevalent and burdensome gastrointestinal disorders. A systematic review and meta-analysis of the evidence for probiotics, prebiotics, and synbiotics in IBS and chronic idiopathic constipation has recently been performed. By far, the most convincing evidence was for the use of probiotics in IBS, which reported that overall probiotics reduced the risk of symptom persistence by 21%. However, only a minority of the trials were at a low risk...
Authors: [No authors listed]
Authors: Devaney E.
In Vitro Screening of Selected Probiotic Properties of Lactobacillus Strains Isolated from Traditional Fermented Cabbage and Cucumber.
Authors: Zielińska D1, Rzepkowska A, Radawska A, Zieliński K.
Abstract: Most important during probiotic selection are gastric acid and bile tolerance, the adhesion to the luminal epithelium to colonize the lower gastrointestinal tract of a human and safety for human consumption. The aim of this study was to evaluate the selected probiotic in vitro properties of Lactobacillus spp. Strains isolated from traditional fermented food. A total 38 strains were isolated from the pickled samples and 14 were identified as Lactobacillus spp. The survival of almost all strains after incubation...
Randomized clinical trial: Effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome.
Authors: Stevenson C1, Blaauw R2, Fredericks E3, Visser J2, Roux S3.
Abstract: OBJECTIVES: Irritable bowel syndrome (IBS) is a common diagnosis in gastroenterology. Its etiology is unknown and therapeutic options limited. Trials suggest probiotics may be beneficial. The aim of this study was to assess the symptomatic efficacy of Lactobacillus plantarum 299 v (L. plantarum 299 v) for the relief of abdominal pain in patients with IBS fulfilling Rome II criteria.METHODS: This study was conducted in a referral hospital. Trial participants were randomized to receive either two capsules of L....
Authors: Bozeman MC1, Benns MV, McClave SA, Miller KR, Jones CM.
Abstract: This article reviews the current literature regarding nutritional therapy in liver disease, with an emphasis on patients progressing to liver failure as well as surgical patients. Mechanisms of malnutrition and sarcopenia in liver failure patients as well as nutritional assessment, nutritional requirements of this patient population, and goals and methods of therapy are discussed. Additionally, recommendations for feeding, micronutrient, branched chain amino acid supplementation, and the use of pre- and probiotics...
The influence of Lactobacillus casei DN 114 001 on the activity of faecal enzymes and genotoxicity of faecal water in the presence of heterocyclic aromatic amines.
Authors: Nowak A1, Sliżewska K2, BÅ‚asiak J3, Libudzisz Z2.
Abstract: High activity of bacterial enzymes in human colon and genotoxicity of faecal water (FW) are biomarkers of the harmful action of microbiota. The aim of the present study was to assess the activity of β-glucuronidase and β-glucosidase and the genotoxicity of FW in vitro after incubation with 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) or 2-amino-1-methyl-6-phenyl-1H-imidazo [4,5-b]pyridine (PhIP) and probiotic Lb. casei DN 114 001 (Actimel). Our results indicate, that IQ and PhIP greatly increased the activity...
Lactic acid bacteria pre-challenged by simulated gastrointestinal conditions is a suitable approach for study of potential probiotic properties.
Authors: Huang HY1, Hsieh HY1, King VA2, Chi LL3, Tsen JH4.
Abstract: Some lactic acid bacteria (LAB) possess probiotic properties beneficial to human health. However, both gastric acid and bile salt have adverse influences on the survival and viability of ingested probiotics. This research investigated the changes in potential probiotic properties of LAB strains after treatment with simulated gastrointestinal (GI) conditions. Three strains of LAB, namely Lactobacillus acidophilus BCRC 10695, Lactobacillusparacasei BCRC 14023, and Bifidobacterium bifidum BCRC 14615, were used...
Probiotic Bacillus pumilus SE5 shapes the intestinal microbiota and mucosal immunity in grouper Epinephelus coioides.
Authors: Yang HL1, Xia HQ, Ye YD, Zou WC, Sun YZ.
Abstract: The health benefits of probiotics are thought to occur, at least in part, through an improved intestinal microbial balance in fish, although the molecular mechanisms whereby probiotics modulate the intestinal microbiota by means of activation of mucosal immunity are rarely explored. In this study, the effects of viable and heat-inactivated probiotic Bacillus pumilus SE5 on the intestinal dominant microbial community and mucosal immune gene expression were evaluated. The fish were fed for 60 d with 3 different...
Authors: Vitetta L1, Bambling M, Alford H.
Abstract: Mental health is closely linked to physical health. Depression (e.g., major depression) is highly prevalent worldwide and a major cause of disability. In a subgroup with treatment-resistant depression, standard pharmacotherapy interventions provide small if any incremental improvement in patient outcomes and may also require the application of an alternate approach. Therefore, in addition to the standard pharmacotherapies prescribed, patients will also be advised on the benefits of psychological counseling,...
Lactobacillus helveticus SBT2171 Inhibits Lymphocyte Proliferation by Regulation of the JNK Signaling Pathway.
Authors: Hosoya T1, Sakai F1, Yamashita M1, Shiozaki T2, Endo T3, Ukibe K1, Uenishi H1, Kadooka Y1, Moriya T1, Nakagawa H2, Nakayama Y2, Miyazaki T2.
Abstract: Lactobacillus helveticus SBT2171 (LH2171) is a lactic acid bacterium with high protease activity and used in starter cultures in the manufacture of cheese. We recently reported that consumption of cheese manufactured using LH2171 alleviated symptoms of dextran sodium sulfate (DSS)-induced colitis in mice. In this study, we have examined whether LH2171 itself exerts an inhibitory effect on the excessive proliferation of lymphocytes. We found that LH2171 inhibited the proliferation of LPS-stimulated mouse T and...
Selection and Characterization of Cheonggukjang (Fast Fermented Soybean Paste)-Originated Bacterial Strains with a High Level of S-adenosyl-L-methionine Production and Probiotics Efficacy.
Authors: Park S1, Kim MJ, Hong J, Kim HJ, Yi SH, Lee MK.
Abstract: This study was executed to develop probiotics producing S-adenosyl-L-methionine (SAMe), a methyl group donor in the 5-methyltetrahydrofolate methylation reaction in animal cells. SAMe is an essential substance in the synthesis, activation, and metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and cell membranes of animals. SAMe is also known as a nutritional supplement for improving human brain function. In this study, SAMe-producing strains were identified in six kinds of Cheonggukjang,...
Oligosaccharides composition in eight Food Legumes species as detected by high resolution mass spectrometry.
Authors: Fan PH1, Zang MT, Xing J.
Abstract: BACKGROUND: As probiotics, soy oligosaccharides become popular as healthy foods to reduce disease risk. However, comprehensive information about oligosaccharides in different food legumes is limited.RESULTS: In this study, eight oligosaccharides were well-detected and quantified in different varieties of eight legume species using high resolution mass spectrometry. It was determined that species could be distinguished by total content of oligosaccharides and their distribution modes. Among the studied species,...
Authors: Oakley BB1, Lillehoj HS, Kogut MH, Kim WK, Maurer JJ, Pedroso A, Lee MD, Collett SR, Johnson TJ, Cox NA.
Abstract: The domestic chicken is a common model organism for human biological research, and of course also forms the basis of a global protein industry. Recent methodological advances have spurred the recognition of microbiomes as complex communities with important influences on the health and disease status of the host. In this mini-review, we provide an overview of the current state of knowledge of the chicken GI microbiome focusing on spatial and temporal variability, the presence and importance of human pathogens,...
Probiotics' Preventive Effect on Pediatric Food Allergy: A Meta-analysis of Randomized Controlled Trials.
Authors: Kong XY, Yang Y, Guan J, Wang RZ.
Abstract: Objective To investigate the preventive effect of probiotics on pediatric food allergy. Methods From MEDLINE bibliographical database, we searched and reviewed all randomized controlled trials on the preventive effects of probiotics on pediatric food allergies up to September 2013 and excluded the studies that do not meet inclusion criteria and extracted the data. Meta-analysis for the results of homogenous studies was performed using RevMan 5.0 and the co-effect was pooled by using fixed-effects model of relative...
Authors: Rodrigues F1, Maia MJ, das Neves J, Sarmento B, Amaral MH, P P Oliveira MB.
Abstract: Objective: The aim of this study was to develop and characterize suppositories for vaginal delivery of Lactobacillus acidophilus. Methods: Formulations were performed in order to select suitable excipients based on suppository formation feasibility and cytotoxicity. Solid body and hollow-type suppositories were prepared by melting and molding using poly(ethylene glycol) (PEG) 400 and 4000 or Witepsol (WIT) H12 as excipients. L. acidophilus was incorporated in the molten mass before molding solid body suppositories...
Effect of probiotic VSL#3 in the treatment of minimal hepatic encephalopathy- a non-inferiority randomized controlled trial.
Authors: Pratap Mouli V1, Benjamin J, Bhushan Singh M, Mani K, Garg SK, Saraya A, Joshi YK.
Abstract: BACKGROUND: Minimal hepatic encephalopathy (MHE) impairs daily functioning and health related quality of life in chronic liver disease (CLD). Lactulose is the standard treatment but has side effects; Probiotics have encouraging role in MHE.AIM: To test whether probiotics is non-inferior to lactulose in improving MHE.METHODS: Patients with CLD (n=227) were screened for MHE using neuropsychometrics tests - Number Connection Tests A and B (or Figure Connection Tests A and B) and/or neurophysiologic test - P-300...
Authors: Bridgman SL, Azad MB, Field CJ, Letourneau N, Johnston DW, Kaplan BJ, Kozyrskyj AL.
Abstract: BACKGROUND: Probiotic products that may modify the intestinal microbiota are becoming increasingly available and known to consumers due to their potential to prevent or treat many pediatric health conditions. As scientific knowledge of the health benefits of probiotics increases, it is important to identify factors that may prevent their successful integration into patient care as well as to ensure effective translation of research findings. The aim of this study was to describe maternal perspectives on probiotics...
Authors: Mitchel EB1, Lavine JE.
Abstract: BACKGROUND: Paediatric nonalcoholic fatty liver disease (NAFLD) is a major public health concern given the recent increase in its prevalence and link to obesity and other metabolic comorbidities. Current treatment strategies involve lifestyle changes. Other surgical and pharmacologic interventions have been proposed; however, limited randomised controlled trials (RCTs) in the paediatric population restrict their use.AIM: To review the current management of paediatric NAFLD, including lifestyle and pharmacologic...
Dietary supplementation of milk fermented with probiotic Lactobacillus fermentum enhances systemic immune response and antioxidant capacity in aging mice.
Authors: Sharma R1, Kapila R2, Kapasiya M1, Saliganti V1, Dass G1, Kapila S1.
Abstract: Although probiotics are known to enhance the host immune response, their roles in modulating immunosenescence, resisting infection, and improving redox homeostasis during aging remain unclear. Therefore, the present study was devised in aging mice to assess the antiimmunosenescence potential from the consumption of milk that is fermented with probiotic Lactobacillus fermentum MTCC 5898 (LF). We hypothesized that probiotic supplementation would boost immunity, improve antioxidant capacity, and resist severity...
Authors: TulumoÄŸlu S1, Kaya HI2, SimÅŸek O3.
Abstract: The aim of this study was to characterize the probiotic characteristics of L. fermentum strains isolated from Tulum cheese. Seven L. fermentum strains were selected among the isolated and identified lactobacillus strains due to their abundance. When the gastric condition was considered, L. fermentum LP3 and LP4 were able to tolerate pH 2.5 and 1% bile salt. All L. fermentum strains had similar enzymatic activity and antibiotic resistance pattern but the highest antagonistic effect was detected within LP3, LP4...